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  • Superoxide Dismutase

    2020-2-18u2002·u2002The enzyme superoxide dismutase (SOD) catalyzes the breakdown of superoxide radicals that are toxic to living cells into harmless components consisting of oxygen and hydrogen peroxide, but because SOD1 also protects cancer cells …

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  • Extracellular superoxide dismutase and its role in cancer ...

    2017-11-1u2002·u2002Notably, ROS is increased in cancer cells. The superoxide dismutase family plays an essential physiological role in mitigating deleterious effects of ROS. Due to the compartmentalization of ROS signaling, EcSOD, the only superoxide dismutase in the extracellular space, has unique characteristics and functions in cellular signal transduction.

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  • Evaluation of a Superoxide Dismutase Mimetic As an Adjunct ...

    Interleukin-2 (IL-2) is currently used to treat patients with metastatic renal cell carcinoma and malignant melanoma. Clinical use of IL-2 is limited by severe side effects, particularly hypotension. Because of such dose-limiting side effects, the full period of IL-2 dosing is frequently curtailed. Our study demonstrates that M40403, a synthetic superoxide dismutase mimetic (SODm), which ...

    Get Price
  • Superoxide Dismutase (SOD), Bovine Erythrocytes

    Superoxide dismutases are enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. Thus, they are an important antioxidant defense in nearly all cells exposed to oxygen.Superoxide dismutases are a group of low molecular weight metalloproteins present in all aerobic cells of plants, animals and micro-organisms. They provide protection against damaging …

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  • Immunohistochemical evaluation of superoxide dismutase (Cu ...

    Superoxide dismutase (Cu/Zn SOD) concentrations in erythrocytes were determined in smears of whole blood samples collected from 16 Polish Holstein-Friesian cows and 22 farm-raised deer in spring. Mouse anti-bovine SOD (Cu-Zn) monoclonal antibodies (2F5, …

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  • Comparative anti-inflammatory activity of different ...

    Author information: (1)Service de Pharmacologie, Faculté de Pharmacie, Marseille, France. Comparison of superoxide dismutases from different sources with respect to biological activity in the rat tourniquet poditis model shows that anti-ischemic activity is very variable although all the enzymes have the same specific enzymic activity.

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  • Superoxide dismutase and catalase as therapeutic agents ...

    1990-1-1u2002·u2002Potential Scavenger Substances for Human or Animal Model Use Superoxide Dismutase: bovine, recombinant human Catalase Low MW SOD mimics, e.g. metal complexes Low MW GSH peroxidase mimics, e.g. ebselen PEG-SOD conjugates Liposome encapsulated products Cationic modified proteins SOD hinged dimers SOD-pyran polymers Combination products, e.g. SOD ...

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  • (PDF) Effects of superoxide dismutase on some biological ...

    The present study observed the effects of superoxide dismutase (SOD) and its inhibitor, diethyldithiocarbamate (DDC), on the metastasis of Lewis Lung cancer and some biological characteristics of A549 lung cancer cell line. It was found that SOD and

    Get Price
  • China Superoxide Dismutase/SOD, Biological Fermentation ...

    China Superoxide Dismutase/SOD, Biological Fermentation Extraction, Anti-Cancer, Scavenging Free Radicals, Anti-Aging Health Food SOD, Find details about China Superoxide Dismutase SOD, Cosmetics from Superoxide Dismutase/SOD, Biological Fermentation Extraction, Anti-Cancer, Scavenging Free Radicals, Anti-Aging Health Food SOD - Xiamen Yiyu Biological Technology Co., …

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  • Superoxide Dismutase Antibody 100-4191

    Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-rabbit serum, purified and partially purified Superoxide Dismutase [Bovine Erythrocytes]. Cross reactivity against Superoxide Dismutase from other tissues and species may …

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  • Therapeutic potentials of superoxide dismutase

    2021-9-12u2002·u2002Introduction. Superoxide dismutases (SODs) are a group of metalloenzymes that are found in all kingdoms of life. SODs form the front line of defense against reactive oxygen species (ROS)-mediated injury.[] These proteins catalyze the dismutation of superoxide anion free radical (O 2-) into molecular oxygen and hydrogen peroxide (H 2 O 2) [Figure 1a] and decrease O 2-level …

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  • Anti Superoxide Dismutase (Cu-Zn) Antibody, clone 2F5 ...

    Mouse anti Bovine superoxide dismutase (Cu/Zn) antibody, clone 2F5 recognizes bovine superoxide dismutase (Cu/Zn), also known by it's gene name SOD1. Bovine superoxide dismutase (Cu/Zn) is a 152 amino acid ~15kDa cytoplasmic protein involved in the …

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  • Immunohistochemical evaluation of superoxide dismutase (Cu ...

    Superoxide dismutase (Cu/Zn SOD) concentrations in erythrocytes were determined in smears of whole blood samples collected from 16 Polish Holstein-Friesian cows and 22 farm-raised deer in spring. Mouse anti-bovine SOD (Cu-Zn) monoclonal antibodies (2F5, …

    Get Price
  • Anti-Superoxide Dismutase 3 Antibody Products

    Compare Anti-Superoxide Dismutase 3 Antibody Products from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.

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  • (PDF) Superoxide Dismutases (SODs) and SOD Mimetics

    2018-11-2u2002·u2002Superoxide dismutase (SOD) is an antioxidant enzyme that catalyzes the dismutation of radical anion superoxide to hydrogen peroxide and oxygen (Borgstahl and Oberley-Deegan 2018). HS was able to ...

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  • Superoxide dismutase and catalase as therapeutic agents ...

    1990-1-1u2002·u2002Potential Scavenger Substances for Human or Animal Model Use Superoxide Dismutase: bovine, recombinant human Catalase Low MW SOD mimics, e.g. metal complexes Low MW GSH peroxidase mimics, e.g. ebselen PEG-SOD conjugates Liposome encapsulated products Cationic modified proteins SOD hinged dimers SOD-pyran polymers Combination products, e.g. SOD ...

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  • CAS No.9054-89-1,Dismutase, superoxide Suppliers,MSDS

    Superoxide dismutase. Min.Order: 1000 Gram FOB Price: USD $ 500.0-500.0/Gram chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

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  • Anti-inflammatory effect of the conjugate of superoxide ...

    1997-10-13u2002·u20021.. IntroductionSuperoxide dismutase (SOD) effectively hydrolyzes the superoxide anion to water and hydrogen peroxide .Because this anion is considered to be the cause of inflammation, it is considered crucial for the effective treatment of inflammatory diseases, ischemia, ulcerative colitis, as well as rheumatism .But SOD could not reveal its anti-inflammatory activity …

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  • Activity, thermostability and isozymes of superoxide ...

    2012-5-1u2002·u2002Activity, thermostability and isozymes of superoxide dismutase (SOD) of 17 edible mushrooms from China were investigated in this study. The results indicated that most of these mushrooms have high SOD activities, especially Pleurotus citrinopileatus, Agaricus bisporus, Pleurotus ostreatus, Volvariella volvacea and Agrocybe aegerita, which contained SOD activities …

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  • Superoxide dismutase and catalase as therapeutic agents ...

    1990-1-1u2002·u2002Potential Scavenger Substances for Human or Animal Model Use Superoxide Dismutase: bovine, recombinant human Catalase Low MW SOD mimics, e.g. metal complexes Low MW GSH peroxidase mimics, e.g. ebselen PEG-SOD conjugates Liposome encapsulated products Cationic modified proteins SOD hinged dimers SOD-pyran polymers Combination products, e.g. SOD ...

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  • The Body's Natural Cancer Fighter: Superoxide Dismutase ...

    2013-9-3u2002·u2002The Body's Natural Cancer Fighter: Superoxide Dismutase (SOD) If you've been around the world of alternative cancer treatments for more than a week, you've probably noticed a theme. Cancer can be caused by exposure to toxins, and it can be prevented by elimination of such toxins.

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  • Superoxide dismutase as a target for the selective killing ...

    2000-9-21u2002·u2002Superoxide dismutases (SOD) are essential enzymes that eliminate superoxide radical (O2-) and thus protect cells from damage induced by free radicals1,2,3. The active O2- …

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  • Cellular Penetration of Fluorescently Labeled Superoxide ...

    Using fluorescently labeled superoxide dismutase (SOD) and flow cytometry, we have shown previously that the enzyme CuZn SOD (EC 1.15.1.1) from bovine erythrocytes binds rapidly to the cell surface with slow uptake into the cell during the following hours. The degree of labeling was most important for monocytes in comparison to other blood cells (erythrocytes, lymphocytes, …

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  • Identification of biomarkers for the antiangiogenic and ...

    2008-2-5u2002·u2002Tetrathiomolybdate (choline salt; ATN-224), a specific, high-affinity copper binder, is currently being evaluated in several phase II cancer trials. ATN-224 inhibits CuZn superoxide dismutase …

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  • PLT to distribute GliSODin - NutraIngredients

    2002-6-6u2002·u2002According to the company, superoxide dismutase is a master defence enzyme and powerhouse antioxidant which occurs naturally in human cells. The production of SOD in the body decreases during the ageing process. GliSODin is derived from melons, although a previous source was bovine liver.

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  • Superoxide dismutase - Infogalactic: the planetary ...

    2020-10-2u2002·u2002Superoxide dismutase (SOD, EC 1.15.1.1) is an enzyme that alternately catalyzes the dismutation (or partitioning) of the superoxide (O 2 −) radical into either ordinary molecular oxygen (O 2) or hydrogen peroxide (H 2 O 2).Superoxide is produced as a by-product of oxygen metabolism and, if not regulated, causes many types of cell damage. Hydrogen peroxide is also …

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  • Elsevier Editorial System(tm) for European Journal of ...

    bovine liver, superoxide dismutase (SOD) from bovine erythrocytes and catalase were from Sigma-Aldrich (Saint-Quentin Fallavier, France). Neutralized bovine collagen-I was

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  • Life Extension Europe

    Life Extension Europe - nutritional supplements, vitamins, minerals, antioxidants, omegas, fish oil, amino acids, herbs, probiotics and more. 500+ su…

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  • (PDF) Oberley LW, Buettner GRRole of superoxide dismutase ...

    Role of Superoxide Dismutase in Cancer: A Review1 Larry W. Oberley2 and Garry R. Bueftner3 Radiation Research Laboratory, University of Iowa, Iowa City, Iowa 52242

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  • Superoxide Dismutase - an overview

    In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. General information. Orgotein, an enzyme (CuZn superoxide dismutase) that is present in all mammalian cells, is obtained from bovine liver by several steps, including chromatography.It can be given parenterally or topically and has been used to treat conditions such as radiation cystitis [1–7], osteoarthritis [8–11], and Peyronie ...

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  • Superoxide Dismutase Benefits, Uses, Foods and Side ...

    2019-7-29u2002·u2002Superoxide dismutase is an enzyme that we make naturally within the body. Is superoxide dismutase an antioxidant? Yes! It's often taken for its ability to fight free radical cell damage. Superoxide dismutase benefits also include reducing inflammation, fighting cancer…

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  • Myocardial Protective Effect of Extracellular Superoxide ...

    2014-2-15u2002·u2002Extracellular superoxide dismutase (ecSOD) binds to heparin sulfate proteoglycans on cellular surface as a unique scavenger of superoxide anions in the extracellular space . Many studies have shown that direct gene transfer of the cDNA encoding membrane-bound …

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  • Superoxide-mediated clastogenesis and anticlastogenic ...

    1996-11-12u2002·u2002The strongest argument for the implication of superoxide in these clastogenic effects was the observation that exposure of blood cultures to a xanthine oxidase reaction, photoreduction of flavins or a phorbol 12-myristate 13-acetate (PMA)-stimulated respiratory burst resulted in chromosomal breakage and sister chromatid exchanges.This could be ...

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  • PLT to distribute GliSODin - NutraIngredients

    2002-6-6u2002·u2002According to the company, superoxide dismutase is a master defence enzyme and powerhouse antioxidant which occurs naturally in human cells. The production of SOD in the body decreases during the ageing process. GliSODin is derived from melons, although a previous source was bovine liver.

    Get Price
  • Anti-Superoxide Dismutase 2/SOD2 Antibody (E-10)

    2017-1-12u2002·u2002Anti-Superoxide Dismutase 2/SOD2 Antibody (E-10) is a mouse monoclonal IgG 2b κ Superoxide Dismutase 2/SOD2 antibody, cited in 64 publications, provided at 200 µg/ml; specific for an epitope mapping between amino acids 22-58 near the N-terminus of SOD-2 of human origin

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  • Recombinant Anti-Superoxide Dismutase 1 antibody

    Immunofluorescent analysis of 4% Paraformaldehyde-fixed, 0.1% TritonX-100 permeabilized NIH/3T3 cells labelling Superoxide Dismutase 1 with ab51254 at 1/100 dilution, followed by ab150077 Goat Anti-Rabbit IgG H&L (Alexa Fluor ® 488) antibody at 1/1000 2 ug/ml dilution (Green). Confocal image showing cytoplasmic and weak nuclear staining in NIH/3T3 cell line ab195889 Anti-alpha Tubulin mouse ...

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  • Research Journal of Pharmaceutical, Biological and ...

    Superoxide dismutase (SOD) activity was determined according to the method described by Marklund and Marklund (1974) by assaying the auto-oxidation and illumination of pyrogallol at 440nm for 3min ...

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  • Superoxide dismutase - wikidoc

    2021-8-17u2002·u2002Superoxide dismutase (SOD, EC 1.15.1.1) is an enzyme that alternately catalyzes the dismutation (or partitioning) of the superoxide (O 2 −) radical into either ordinary molecular oxygen (O 2) or hydrogen peroxide (H 2 O 2).Superoxide is produced as a by-product of oxygen metabolism and, if not regulated, causes many types of cell damage. Hydrogen peroxide is also damaging and is degraded by ...

    Get Price
  • Catalase Activity Assays - Cell Biolabs

    2021-9-15u2002·u2002Catalase is a ubiquitous enzyme that destroys hydrogen peroxides formed during oxidative stress. Our OxiSelect™ Catalase Activity Assay Kits measure catalase activity in less than one hour from a variety of samples including blood, cells and tissues. Direct spectrophotometric detection of catalase activity with ultraviolet light can cause interference from proteins and other biological ...

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  • Superoxide Dismutase

    2020-2-18u2002·u2002The enzyme superoxide dismutase (SOD) catalyzes the breakdown of superoxide radicals that are toxic to living cells into harmless components consisting of oxygen and hydrogen peroxide, but because SOD1 also protects cancer cells and is overexpressed in lung cancer cells, it was identified as a therapeutic target for anti-lung cancer compounds .

    Get Price
  • Extracellular superoxide dismutase and its role in cancer ...

    2017-11-1u2002·u2002Notably, ROS is increased in cancer cells. The superoxide dismutase family plays an essential physiological role in mitigating deleterious effects of ROS. Due to the compartmentalization of ROS signaling, EcSOD, the only superoxide dismutase in the extracellular space, has unique characteristics and functions in cellular signal transduction.

    Get Price
  • Evaluation of a Superoxide Dismutase Mimetic As an

    Interleukin-2 (IL-2) is currently used to treat patients with metastatic renal cell carcinoma and malignant melanoma. Clinical use of IL-2 is limited by severe side effects, particularly hypotension. Because of such dose-limiting side effects, the full period of IL-2 dosing is frequently curtailed. Our study demonstrates that M40403, a synthetic superoxide dismutase mimetic (SODm), which ...

    Get Price
  • Superoxide Dismutase (SOD), Bovine Erythrocytes

    Superoxide dismutases are enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. Thus, they are an important antioxidant defense in nearly all cells exposed to oxygen.Superoxide dismutases are a group of low molecular weight metalloproteins present in all aerobic cells of plants, animals and micro-organisms. They provide protection against damaging reactions ...

    Get Price
  • Immunohistochemical evaluation of superoxide dismutase

    Superoxide dismutase (Cu/Zn SOD) concentrations in erythrocytes were determined in smears of whole blood samples collected from 16 Polish Holstein-Friesian cows and 22 farm-raised deer in spring. Mouse anti-bovine SOD (Cu-Zn) monoclonal antibodies (2F5, Serotec) were used in 1:50 dilution.

    Get Price
  • Comparative anti-inflammatory activity of different ...

    Author information: (1)Service de Pharmacologie, Faculté de Pharmacie, Marseille, France. Comparison of superoxide dismutases from different sources with respect to biological activity in the rat tourniquet poditis model shows that anti-ischemic activity is very variable although all the enzymes have the same specific enzymic activity.

    Get Price
  • Superoxide dismutase and catalase as therapeutic agents ...

    1990-1-1u2002·u2002Potential Scavenger Substances for Human or Animal Model Use Superoxide Dismutase: bovine, recombinant human Catalase Low MW SOD mimics, e.g. metal complexes Low MW GSH peroxidase mimics, e.g. ebselen PEG-SOD conjugates Liposome encapsulated products Cationic modified proteins SOD hinged dimers SOD-pyran polymers Combination products, e.g. SOD ...

    Get Price
  • (PDF) Effects of superoxide dismutase on some biological ...

    The present study observed the effects of superoxide dismutase (SOD) and its inhibitor, diethyldithiocarbamate (DDC), on the metastasis of Lewis Lung cancer and some biological characteristics of A549 lung cancer cell line. It was found that SOD and

    Get Price
  • China Superoxide Dismutase/SOD, Biological Fermentation ...

    China Superoxide Dismutase/SOD, Biological Fermentation Extraction, Anti-Cancer, Scavenging Free Radicals, Anti-Aging Health Food SOD, Find details about China Superoxide Dismutase SOD, Cosmetics from Superoxide Dismutase/SOD, Biological Fermentation Extraction, Anti-Cancer, Scavenging Free Radicals, Anti-Aging Health Food SOD - Xiamen Yiyu Biological Technology Co., Ltd.

    Get Price
  • Anti-inflammatory effect of the conjugate of superoxide ...

    1997-10-13u2002·u20021.. IntroductionSuperoxide dismutase (SOD) effectively hydrolyzes the superoxide anion to water and hydrogen peroxide .Because this anion is considered to be the cause of inflammation, it is considered crucial for the effective treatment of inflammatory diseases, ischemia, ulcerative colitis, as well as rheumatism .But SOD could not reveal its anti-inflammatory activity clinically due to its ...

    Get Price
  • Superoxide Dismutase as an Intervention for Radiation ...

    2021-3-5u2002·u2002Superoxide Dismutase as an Intervention for Radiation Therapy-Associated Toxicities: Review and Profile of Avasopasem Manganese as a Treatment Option for Radiation-Induced Mucositis. Abstract: Toxicities associated with radiation therapy are common, symptomatically devastating, and costly.

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  • Expression of a Cu,Zn superoxide dismutase typical for ...

    2007-11-12u2002·u2002Infections can aggravate the course of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Mutations in the anti-oxidant enzyme Cu,Zn superoxide dismutase (EC 1.15.1.1, SOD1) are associated with familial ALS. Streptococcus pneumoniae, the most frequent respiratory pathogen, causes damage by the action of the cholesterol-binding virulence factor pneumolysin and by ...

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  • Superoxide dismutase – NutraWiki

    Superoxide Dismutase has also been used to treat arthritis, prostate problems, corneal ulcers, burn injuries, inflammatory diseases, inflammatory bowel disease, and long-term damage from exposure to smoke and radiation, and to prevent side effects of cancer drugs.

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  • Abundance of mitochondrial superoxide dismutase is a ...

    2019-1-30u2002·u2002Endometrioid ovarian carcinoma and clear cell ovarian carcinoma are both classified as endometriosis-associated ovarian cancers (EAOCs). Despite the high rates of recurrence and mortality of EAOC, only a few prognostic biomarkers have been reported. Mitochondrial superoxide dismutase (SOD2) plays an important role in maintaining mitochondrial function through oxidative stress …

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  • Inhibition of AP‐1 and NF‐κB by manganese‐containing ...

    1998-12-1u2002·u2002Inhibition of AP-1 and NF-κB activity in MnSOD stable transfectants. Twenty thousand cells of wild-type (MCF-7), vector control (Vector), or MnSOD transfected (MnSOD) cell lines were cotransfected with collagenase AP-1-luciferase (A), NF-κB-luciferase (B), or SP-1-luciferase (C) and β-galactosidase reporters.Luciferase activity was measured using 100 µl whole cell lysate and 100 µl ...

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  • Superoxide Dismutase 1 Nanozyme for Treatment of Eye ...

    2015-12-1u2002·u2002Use of antioxidants to mitigate oxidative stress during ocular inflammatory diseases has shown therapeutic potential. This work examines a nanoscale therapeutic modality for the eye on the base of antioxidant enzyme, superoxide dismutase 1 (SOD1), termed 'nanozyme.' The nanozyme is produced by electrostatic coupling of the SOD1 with a cationic block copolymer, poly(L-lysine)-poly ...

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  • Manganese Superoxide Dismutase in Cancer Prevention ...

    2014-3-5u2002·u2002Cancer is preventable as indicated by human papilloma virus (HPV) vaccination and tamoxifen/raloxifen treatment in breast cancer prevention. The activities of superoxide dismutases (SODs) are often lowered during early cancer development, making it a rational candidate for cancer …

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  • Total Antioxidant Capacity (TAC) Assay - Cell Biolabs

    2021-9-15u2002·u2002The OxiSelect™ Total Antioxidant Capacity (TAC) Assay measures the total antioxidant capacity of biomolecules from a variety of samples via a SET mechanism. In the presence of antioxidants, copper(II) is reduced to copper(I). In turn, the copper(I) ions react with a chromogen to produce a color with maximum absorbance at 490nm.

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  • Roles of zinc and copper in modulating the oxidative ...

    2010-3-1u2002·u2002Copper, zinc superoxide dismutase (SOD1) isolated from bovine blood has been the subject of extensive investigation since the discovery of its catalytic function in 1969 . From a comparison of the sequences between bovine and human enzymes, the homology is found to be 90% [ 5 ], and the structure of SOD1 proteins from many species are highly ...

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  • Chamomile decoction extract inhibits human neutrophils

    2017-8-23u2002·u2002[19], anti-allergic [20], anti-microbial [21], anti-cancer [22], and anti-inflammatory [23]. The present study was undertaken to investigate the protective effect of chamomile decoction extract on haematological parameter disorders and erythrocytes-induced oxidative stress after the acute alcohol ad-ministration. We also studied the implication ...

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